- American Society for the Prevention of Cruelty to Animals
- Western Hemisphere's first humane organization. Aims to reduce injustices or exploitation on animals. Site presents information on organization activities, programs, and ways to help.
- Animals and Society Institute
- Independent research and educational organization dedicated to advancing the status of animals in public policy. Also aims to promote the study of human-animal relationships.
- The Association of Sanctuaries (TAOS)
- Not-for-profit group created to assist sanctuaries in providing quality rescue and care for displaced animals.
- Association of Veterinarians for Animal Rights (AVAR)
- Organization promoting animal rights through public education and the advancement of the veterinary profession.
- Born Free USA
- Nonprofit organization and national animal advocacy. Advances the protection of animals from cruelty and exploitation.
- Coalition for Animal Justice
- Aims to represent the welfare of companion animals. Advocates the implementation of maximum jail sentences for those who abuse or exploit companion animals.
- Doris Day Animal League
- Citizen's lobbying organization founded to improve the humane treatment of animals through legislative initiatives.
- Eastern Shore Sanctuary and Education Center
- Organization aims to provide sanctuary for hens and roosters that have escaped or have been rescued from abusive situations.
- Friends of Animals
- Highlights the activities of the animal rights and welfare advocacy group. Includes history, objectives, programs, strategies, leaders, blogs and news.
- The Humane Society of the United States
- Addresses the issues of inhumane practices and conditions affecting farm and companion animals, wildlife, and endangered species.
- Last Chance for Animals
- Organization established to oppose the use of animals for scientific experiments, entertainment, clothing, and food.
- National Organization to Protect ALIEN Wildlife Species (NOPAWS)
- Advocacy group working for the protection of "animals living in the wild somewhere other than their native country.".
- New England Federation of Humane Societies
- Private nonprofit organization founded to promote a more humane world--with emphasis on animal welfare--through education, training, and information and networking opportunities.
- Supporting and Promoting Ethics for the Animal Kingdom (SPEAK)
- All-volunteer organization providing public awareness and education on the conditions of animals and the environment.
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