Scleroderma is a chronic disease that can be generally described as the pathological thickening and hardening of the skin. It is a systemic autoimmune disease characterized by the development of excess fibrous connective tissues, antibodies acting against one's own tissues, and alterations. The swelling and collagen buildup brought about by the disease causes the loss of skin elasticity. Two major forms of the disease exist: the limited systemic sclerosis/scleroderma and diffuse systemic sclerosis/scleroderma.
The first form of scleroderma (formerly known as CREST syndrome) introduces cutaneous manifestations primarily affecting the face, arms, and hands. Pulmonary arterial hypertension is the most serious complication that may develop in a person affected by this form of scleroderma and it can be observed occurring in over 30% of patients.
Diffuse systemic sclerosis/scleroderma on the other hand is a more serious form of scleroderma as it can be disabling. This form is rapidly progressing. It tends to affect a large area of the skin and can even affect internal organs such as the kidneys, esophagus, lungs, and the heart.
Scleroderma can be inherited though the genes responsible for the disease are yet to be identified. The causes are likewise not yet determined. There is no known for the disease itself but treatments to address symptoms or the manifestations of scleroderma can be used.
This category features websites that provide information and resources relevant to scleroderma. Also listed are organizations and sources for new information and research updates.