- Basilisk II
- Open source 68k Macintosh emulator runs on versions of OS X.
- Bernie Rescue
- Emulates Apple IIgs on PowerPCs.
- Bochs
- Freeware, open source IA-32 (x86) emulator written in C++ runs on most platforms, including Mac OS 9 and X.
- DOSBox
- Offers DOSBox emulation for Mac OS X users.
- Einstein Emulator UP1
- Freeware emulates Newton N2 platform and includes StrongARM 110 emulator as well as the Newton OS subsystems.
- Frodo
- Provides improved emulation of Commodore 64 for the Mac. Includes processor-level 1541 emulation to handle most fast loaders.
- KEGS
- Emulates Apple IIgs for Mac OS X, Win32, Linux and Unix.
- MacMame
- Allows users to play all the vintage arcade games, including Asteroids, Spy Hunter, Star Wars, Donkey Kong, Galaxian and more.
- Mugrat
- Freeware emulator works for Colecovision games.
- OSXII
- Features Apple IIe emulation for Mac OS X utilizing Cocoa and OpenGL.
- Stella
- Vintage Atari 2600 games are now available for play on Mac OS X via Stella.
- Virtual II
- Mac OS X users can emulate Apple II and IIe systems. Supports graphics modes and game paddles.
- Virtual PC for Mac
- Virtual PC allows Mac users to boot with a virtual Windows system for PC gaming.
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